IL-17 in Protective Immunity to Vaginal Candidiasis
نویسندگان
چکیده
منابع مشابه
Th17 Cells and IL-17 in Protective Immunity to Vaginal Candidiasis
BACKGROUND Th17 cells play a major role in coordinating the host defence in oropharyngeal candidiasis. In this study we investigated the involvement of the Th17 response in an animal model of vulvovaginal candidiasis (VVC). METHODS To monitor the course of infection we exploited a new in vivo imaging technique. RESULTS i) The progression of VVC leads to a strong influx of neutrophils in the...
متن کاملCorrection: Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis.
Oropharyngeal candidiasis (OPC), caused by the commensal fungus Candida albicans, is an opportunistic infection associated with infancy, AIDS, and IL-17-related primary immunodeficiencies. The Th17-associated cytokines IL-23 and IL-17 are crucial for immunity to OPC, but the mechanisms by which they mediate immunity are poorly defined. IL-17RA-deficient humans and mice are strongly susceptible ...
متن کاملIL-22 and IDO1 Affect Immunity and Tolerance to Murine and Human Vaginal Candidiasis
The ability to tolerate Candida albicans, a human commensal of the gastrointestinal tract and vagina, implicates that host defense mechanisms of resistance and tolerance cooperate to limit fungal burden and inflammation at the different body sites. We evaluated resistance and tolerance to the fungus in experimental and human vulvovaginal candidiasis (VVC) as well as in recurrent VVC (RVVC). Res...
متن کاملThe Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans.
The discovery of interleukin (IL)-17-mediated immunity has provided a robust framework upon which our current understanding of the mechanism involved in host defense against mucocutaneous candidiasis (CMC) has been built. Studies have shed light on how pattern recognition receptors expressed by innate immune cells recognize various components of Candida cell wall. Inborn errors of immunity affe...
متن کاملGain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here, using whole-exome sequencing, we identified heterozygous germline mutations in STAT1 in 47 patients from 20 kindreds with AD CMCD. Previously described heterozygous STAT1 mutant alleles are loss-of-function and cause AD predisposition ...
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ژورنال
عنوان ژورنال: Baghdad Science Journal
سال: 2016
ISSN: 2411-7986,2078-8665
DOI: 10.21123/bsj.13.1.31-35